8/31/2023 0 Comments Eloquent areas of brain![]() However, brain movement during tumor resection reduces the effectiveness of using preoperative images for intraoperative surgical guidance and therefore using additional methods for intraoperative definition of white matter state could be useful. ![]() This data is crucial for neurosurgical planning in order to identify and prevent damaging of the eloquent white matter tracts. Moreover DTI depicts the incorporation of white matter fibers within the infiltrative brain tumors, seen especially in low-grade tumors, and their destruction by the high-grade gliomas. DTI is a noninvasive magnetic resonance imaging (MRI) modality which is widely used in preoperative planning in brain tumor surgery providing the information about the location and orientation of white matter tracts in relation to the tumor mass. PS OCT allows to visualize white matter tracts in the brain and moreover has demonstrated good cross-validation with diffusion tensor imaging (DTI) on a postmortem human medulla oblongata sample. These OCT modalities offer sensitivity to tissue birefringence providing contrasts imaging of myelinated and birefringent nerve fibers. However OCT is seemed to be an excellent method of myelin visualization, that can be realized using so called OCT functional extension – polarization-sensitive (PS) OCT (and also polarization-sensitive optical coherence microscopy) and cross-polarization (CP) OCT. Therefore, further studies and technological refinement are needed to increase the diagnostic capabilities of OCT and to provide rapid and efficient detection of brain tumors during surgery. OCT currently has difficulties in clearly distinguishing between the grey matter (both cortex, thalamus or basal ganglia) and tumorous tissue. OCT can provide differentiation between tumorous and non-tumorous tissues through both qualitative and quantitative assessment of the OCT signal by building color-coded maps. ![]() It can provide neurosurgeon with real-time high-resolution images clarifying the boundaries of the infiltrative brain tumors within surrounding tissues. Optical coherence tomography (OCT) is one of the most promising, innovative and rapidly emerging intraoperative imaging modalities for neurosurgical guidance during brain tumor surgery. The detection of white matter microstructure during surgery looks promising therefore additional CP OCT performance build-up can be considered. However, in vivo studies can show conversely results. No significant differences based on CP OCT attenuation and inter-channel attenuation difference coefficients were demonstrated between white matter from different brain areas. Two optical coefficients (attenuation and inter-channel attenuation difference) were calculated for each A-scan and two types of color-coded maps based on them were built. ![]() The brain specimens contained white matter of different organization and localization: brainstem, corpus callosum, frontal and parietal tracts, subcortical white matter. The ex vivo CP OCT images were collected from autopsy subjects of the human brain. The aim of this study was to visualize white matter organization of eloquent brain areas with CP OCT using post-processing methods. It looks perspective not just to detect white matter, but also receive information about its condition – the myelination rate and presence of ordered fibers. Crosspolarization (CP) OCT is a so-called functional extension of OCT that seems to have benefits in visualization of myelin. Since gliomas often tend to grow close to eloquent brain areas, the question of the proximity of the tumor to white matter tracts sharply arise during tumor resection to prevent their damage. Optical coherence tomography (OCT) is a promising method for clarifying the boundaries of the infiltrative brain tumors within surrounding white matter.
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